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Association between microRNA binding site polymorphisms in immunoinflammatory genes and recurrence risk of ischemic

Ruixia Zhu1, Yating Zhao1, Tongling Xiao1

  • 1Department of Neurology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.

Genomics
|December 29, 2019
PubMed

Insights

Genetic variations in immunoinflammatory genes, like ADIPOR2 rs12342, may predict ischemic stroke recurrence. This specific polymorphism shows promise as a biomarker for reduced stroke risk, particularly in small-vessel disease patients.

Area of Science:

  • Genetics
  • Immunology
  • Neurology

Background:

  • MicroRNA binding site polymorphisms in immunoinflammatory genes are potential biomarkers for complex diseases.
  • The role of these polymorphisms in stroke onset and prognosis is not well understood.

Purpose of the Study:

  • To investigate the association of five functional polymorphisms in immunoinflammatory genes with ischemic stroke onset and recurrence.
  • To identify potential genetic biomarkers for predicting stroke recurrence risk.

Main Methods:

  • Genotyping of five polymorphisms (CXCR2 rs1126579, TLR4 rs11536889, ADIPOR2 rs12342, MMP-2 rs7201, MMP-9 rs1056628) in 657 ischemic stroke patients.
  • Statistical analysis including multivariate Cox regression to assess associations with stroke onset and recurrence.
  • Evaluation of the predictive ability of ADIPOR2 rs12342 when added to clinical models.

Main Results:

  • None of the five polymorphisms were associated with the age of ischemic stroke onset.
  • The ADIPOR2 rs12342 polymorphism was significantly associated with a decreased risk of stroke recurrence, especially in patients with small-vessel disease.
  • The variant genotype GG/GA of rs12342 was identified as an independent protective factor for stroke recurrence, improving prediction models.

Conclusions:

  • ADIPOR2 rs12342 may serve as a novel genetic biomarker for predicting ischemic stroke recurrence.
  • This polymorphism could also be a potential therapeutic target for reducing stroke recurrence.
  • Further research is needed to validate these findings and elucidate the underlying biological mechanisms.
Keywords:
Ischemic strokePolymorphismPrognosismicroRNA

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