Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance01:23

Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance

567
The elimination half-life and drug clearance of drugs following nonlinear kinetics can vary with dosage. The Michaelis-Menten parameters and drug concentration influence these factors. As the dose increases, the elimination half-life tends to lengthen, resulting in a reduction in clearance and a disproportionately larger area under the curve. The total clearance can be derived from the Michaelis-Menten equation for drugs following a one-compartment model.
A study on guinea pigs examined the...
567
Drug Therapy01:28

Drug Therapy

219
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
219
Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

117
Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
117
Dosage Regimens: Partial Pharmacokinetic Parameters01:01

Dosage Regimens: Partial Pharmacokinetic Parameters

114
It is not uncommon for complete drug pharmacokinetic profiles to remain elusive in pharmacokinetics. This necessitates certain educated assumptions by pharmacokineticists to determine appropriate dosage regimens without comprehensive pharmacokinetic data from animal or human studies. One prevalent assumption is setting the bioavailability factor, denoted as F, to 1 or 100%. This assumption caters to the scenario where a drug doesn't achieve full systemic absorption, resulting in the patient...
114
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

185
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
185
Determination of Multiple Dosing Parameters: Loading and Maintenance Doses01:25

Determination of Multiple Dosing Parameters: Loading and Maintenance Doses

152
A loading dose is an essential pharmacological strategy to rapidly achieve the target plasma drug concentration necessary for an immediate therapeutic effect. This approach is especially critical for drugs characterized by slow absorption or extended half-lives, where delaying therapeutic plasma levels could compromise treatment outcomes. By administering a loading dose, clinicians ensure a prompt onset of drug action, even for agents with complex pharmacokinetic profiles.Achieving steady-state...
152

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fast Facts and Concepts #535 Responding to Common Patient Concerns for The Fentanyl Patch.

Journal of palliative medicine·2026
Same author

Potential Pharmacogenomics (PGx), Human Leukocyte Antigen (HLA) Antiviral to Cephalosporin Crossover Reaction.

Journal of pharmacy practice·2026
Same author

Outcomes of Risankizumab in Patients with Crohn's Disease and Prior Ustekinumab Exposure in a Multicenter Academic Institution.

Digestive diseases and sciences·2026
Same author

Patients with Crohn's Disease and Ileostomy Can Respond to Upadacitinib.

Digestive diseases and sciences·2025
Same author

Somatization in Polypharmacy: Hiding in Plain Sight.

Innovations in pharmacy·2024
Same author

Polypharmacy as Formal Training and a Model of Practice.

The Senior care pharmacist·2024

Related Experiment Video

Updated: Jan 1, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

13.3K

Polypharmacy as a Clinical Pharmacist Specialist Practice.

Michael J Schuh, Sheena Crosby

    The Senior Care Pharmacist
    |December 30, 2019
    PubMed
    Summary

    This review details the evolution of ambulatory care pharmacy services into specialized polypharmacy care, particularly for older patients with complex medication needs. Pharmacists now act as expert troubleshooters for intricate medication regimens.

    Area of Science:

    • Clinical Pharmacy
    • Pharmacotherapy
    • Geriatric Medicine

    Background:

    • Ambulatory care pharmacy services have expanded significantly.
    • Patients, especially those over 65, often present with polypharmacy and complex medical needs.
    • The healthcare landscape has evolved with sophisticated medications, direct-to-consumer marketing, supplements, and pharmacogenomics.

    Purpose of the Study:

    • To review the development of an ambulatory care pharmacist service into a specialized polypharmacy service.
    • To highlight the increasing complexity and scope of pharmacist roles in managing multiple medications.
    • To identify the factors driving the need for advanced pharmacist expertise in tertiary care settings.

    Main Methods:

    • Review of an established ambulatory care pharmacist service.

    More Related Videos

    Diagonal Method to Measure Synergy Among Any Number of Drugs
    12:08

    Diagonal Method to Measure Synergy Among Any Number of Drugs

    Published on: June 21, 2018

    19.4K
    Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations
    11:15

    Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations

    Published on: July 24, 2021

    5.3K

    Related Experiment Videos

    Last Updated: Jan 1, 2026

    Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
    11:17

    Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

    Published on: August 30, 2018

    13.3K
    Diagonal Method to Measure Synergy Among Any Number of Drugs
    12:08

    Diagonal Method to Measure Synergy Among Any Number of Drugs

    Published on: June 21, 2018

    19.4K
    Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations
    11:15

    Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations

    Published on: July 24, 2021

    5.3K
  • Analysis of the service's evolution into a polypharmacy submodel.
  • Description of the practice setting: a multispecialty, tertiary care clinic in Florida.
  • Main Results:

    • The ambulatory care pharmacist service has successfully evolved into a comprehensive pharmacotherapy and polypharmacy service.
    • The service addresses complex medication issues in patients with multiple comorbidities, often the elderly.
    • Pharmacists are increasingly functioning as expert troubleshooters in pharmacology.

    Conclusions:

    • Polypharmacy management is a viable and necessary clinical specialty for pharmacists.
    • Advances in technology and the increasing complexity of medications necessitate specialized pharmacist expertise.
    • Pharmacists play a crucial role in optimizing medication therapy for patients with multiple health conditions.