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Photoreceptor outer nuclear layer thickness changes in optic neuritis follow up.
Masoud Aghsaei Fard1, Alireza Golizadeh1, Samira Yadegari1
1Farabi Eye Hospital, Tehran University of Medical science, Tehran, Iran.
Multiple Sclerosis and Related Disorders
|December 30, 2019
Summary
Optic neuritis (ON) causes ganglion cell inner plexiform layer thinning. Outer nuclear layer thickness transiently increases then normalizes, predicting visual acuity outcomes at six months.
Area of Science:
- Ophthalmology
- Neuroscience
- Retinal Imaging
Background:
- Optic neuritis (ON) is known to cause ganglion cell inner plexiform layer (GCIPL) thinning.
- Longitudinal changes in outer retinal layers following ON require further investigation.
Purpose of the Study:
- To determine longitudinal changes in retinal layer thickness in patients with optic neuritis (ON).
- To investigate the relationship between retinal layer thickness changes and visual function after ON.
Main Methods:
- Thirty patients with ON underwent optical coherence tomography (OCT) and visual function testing.
- Measurements were taken at baseline, one month, and six months post-ON.
Main Results:
- GCIPL thickness significantly decreased at one month post-ON.
- Outer nuclear layer (ONL) thickness showed a transient increase at one month, returning to baseline by six months.
- GCIPL thinning correlated with baseline visual acuity, while ONL thickness change predicted six-month visual outcome.
Conclusions:
- Optic neuritis leads to transient changes in the outer nuclear layer (photoreceptor nuclei layer) that revert to baseline.
- These transient ONL changes can predict visual acuity at six months post-ON.
