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Related Concept Videos

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DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
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Related Experiment Video

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Multimodal Imaging in Choroideremia.

Katharina G Foote1,2, Austin Roorda3, Jacque L Duncan4

  • 1School of Optometry and Vision Science Graduate Group, University of California, Berkeley, CA, USA. kfoote@berkeley.edu.

Advances in Experimental Medicine and Biology
|December 30, 2019
PubMed
Summary
This summary is machine-generated.

Choroideremia (CHM) involves progressive retinal degeneration. Advanced imaging techniques offer sensitive monitoring of retinal structure and function in affected patients.

Keywords:
Adaptive optics scanning laser ophthalmoscopyChoriocapillarisChoroideremiaDegenerationFundus autofluorescenceMicroperimetryOptical coherence tomographyPhotoreceptorsRetinal pigment epithelium

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Area of Science:

  • Ophthalmology
  • Genetics
  • Medical Imaging

Background:

  • Choroideremia (CHM) is a genetic disorder causing progressive degeneration of the retinal pigment epithelium (RPE), choriocapillaris (CC), and photoreceptors.
  • Lack of animal models necessitates direct patient imaging for understanding CHM pathophysiology and cell survival.

Purpose of the Study:

  • To discuss the utility of combined imaging techniques for analyzing retinal structure and function in CHM patients.
  • To highlight sensitive measures for monitoring disease progression in Choroideremia.

Main Methods:

  • Fundus-guided microperimetry for macular sensitivity.
  • Adaptive optics scanning laser ophthalmoscopy (AOSLO) for cone photoreceptor structure.
  • Fundus autofluorescence (FAF) for RPE analysis.
  • Swept-source optical coherence tomography angiography (SS-OCTA) for CC perfusion.

Main Results:

  • The discussed imaging modalities allow for detailed analysis of key retinal components affected by CHM.
  • Combined imaging provides comprehensive insights into the structural and functional changes in Choroideremia.

Conclusions:

  • Integrated imaging approaches are crucial for sensitive monitoring of retinal structure and function in Choroideremia patients.
  • These techniques can aid in tracking disease progression and evaluating potential therapeutic interventions.