Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CRB1-Associated Inherited Retinal Dystrophies: Prospective Natural History Study With 4 Years of Follow-Up.

Clinical & experimental ophthalmology·2026
Same author

Nonsense Mutation in <i>USH2A</i> Exon-13 Activates the Innate Immune Response in Müller Glial Cells.

International journal of molecular sciences·2026
Same author

Eyes shut homolog (EYS): Connecting molecule to disease.

Progress in retinal and eye research·2025
Same author

miRNA-642a-3p protects β cells from glucolipotoxicity.

Molecular therapy. Nucleic acids·2025
Same author

miR-429 RNA therapy as generic strategy to protect against photoreceptor loss.

Molecular therapy. Nucleic acids·2025
Same author

Genetic Landscape of Nonsyndromic Retinitis Pigmentosa in Portugal.

Advances in experimental medicine and biology·2025

Related Experiment Video

Updated: Jan 1, 2026

M&#252;ller Glia Cell Activation in a Laser-induced Retinal Degeneration and Regeneration Model in Zebrafish
06:27

Müller Glia Cell Activation in a Laser-induced Retinal Degeneration and Regeneration Model in Zebrafish

Published on: October 27, 2017

10.3K

Microglial Cell Dysfunction in CRB1-Associated Retinopathies.

C Henrique Alves1,2,3,4, Jan Wijnholds5,6

  • 1Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal. henriquefafe@gmail.com.

Advances in Experimental Medicine and Biology
|December 30, 2019
PubMed
Summary

CRB1-associated retinopathies cause blindness in 80,000 individuals. This review summarizes current knowledge on inflammation and microglia roles in CRB1 patients and models, highlighting knowledge gaps.

Keywords:
Crumbs homologue-1Leber congenital amaurosisMicrogliaRetinaRetinal inflammationRetinitis pigmentosa

More Related Videos

In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma
12:48

In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma

Published on: May 11, 2015

11.0K
In Vivo Imaging of Cx3cr1gfp/gfp Reporter Mice with Spectral-domain Optical Coherence Tomography and Scanning Laser Ophthalmoscopy
06:19

In Vivo Imaging of Cx3cr1gfp/gfp Reporter Mice with Spectral-domain Optical Coherence Tomography and Scanning Laser Ophthalmoscopy

Published on: November 11, 2017

11.1K

Related Experiment Videos

Last Updated: Jan 1, 2026

M&#252;ller Glia Cell Activation in a Laser-induced Retinal Degeneration and Regeneration Model in Zebrafish
06:27

Müller Glia Cell Activation in a Laser-induced Retinal Degeneration and Regeneration Model in Zebrafish

Published on: October 27, 2017

10.3K
In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma
12:48

In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma

Published on: May 11, 2015

11.0K
In Vivo Imaging of Cx3cr1gfp/gfp Reporter Mice with Spectral-domain Optical Coherence Tomography and Scanning Laser Ophthalmoscopy
06:19

In Vivo Imaging of Cx3cr1gfp/gfp Reporter Mice with Spectral-domain Optical Coherence Tomography and Scanning Laser Ophthalmoscopy

Published on: November 11, 2017

11.1K

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Immunology

Background:

  • Inherited retinal diseases affect 2 million worldwide, with Crumbs homologue-1 (CRB1) gene mutations causing blindness in 80,000.
  • Microglia, the retina's immune cells, are implicated in various retinal diseases like retinitis pigmentosa.
  • The specific role of microglia in CRB1-associated retinopathies remains largely unexplored.

Purpose of the Study:

  • To consolidate existing literature on inflammation in CRB1-associated retinopathies.
  • To elucidate the known functions and implications of microglia in CRB1 patients and relevant animal models.

Main Methods:

  • Literature review of studies on CRB1 mutations and retinal diseases.
  • Analysis of research focusing on inflammatory processes in the retina.
  • Examination of studies investigating microglial involvement in CRB1-related conditions and models.

Main Results:

  • Limited data exists regarding microglial involvement in CRB1-associated retinopathies.
  • Inflammatory pathways are implicated in the pathogenesis of CRB1 mutations.
  • Further research is needed to fully understand microglia's contribution to disease progression.

Conclusions:

  • Understanding microglia's role is crucial for developing targeted therapies for CRB1-associated retinopathies.
  • The current literature highlights significant knowledge gaps concerning inflammation and immune response in these conditions.
  • Future studies should focus on characterizing microglial behavior and inflammatory mediators in CRB1 disease models.