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Mechanisms of increased bioavailability through amorphous solid dispersions: a review
Andreas Schittny1,2, Jörg Huwyler1, Maxim Puchkov1
1Department of Pharmaceutical Sciences, Division of Pharmaceutical Technology, University of Basel, Basel, Switzerland.
Drug Delivery
|December 31, 2019
Summary
Amorphous solid dispersions (ASDs) enhance drug bioavailability but are underutilized. This review clarifies ASD mechanisms, aiding rational formulation development and future research in drug delivery.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Biopharmaceutics
Background:
- Amorphous solid dispersions (ASDs) are crucial for improving oral bioavailability of poorly soluble drugs.
- Limited understanding of in vivo mechanisms and a lack of unified nomenclature hinder ASD research and development.
- Current knowledge gaps impede the widespread clinical application of ASDs.
Purpose of the Study:
- To review and conceptualize the mechanisms of drug liberation and absorption from ASDs in vivo.
- To address the lack of unified nomenclature in ASD research.
- To provide a foundation for rational ASD formulation development and future mechanistic studies.
Main Methods:
- Literature review and conceptualization of ASD mechanisms.
- Synthesis of data on drug dissolution, supersaturation, stabilization, and uptake from ASDs.
- Analysis of excipient effects and drug distribution within ASD systems.
Main Results:
- Detailed conceptualization of ASD dissolution, supersaturated solution formation, and stabilization mechanisms.
- Elucidation of factors influencing drug uptake and distribution from ASD solutions.
- Identification of key excipient roles in ASD performance.
Conclusions:
- Improved mechanistic understanding facilitates rational ASD formulation development.
- Standardized nomenclature is essential for consistent research interpretation and classification.
- This review serves as a basis for advancing drug delivery research using ASDs.
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