Related Experiment Video
Updated: Jan 1, 2026
12:26
Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
Published on: May 3, 2018
19.2K
The double dealing of cyclin D1
Guergana Tchakarska1, Brigitte Sola2
1Department of Human Genetics, McGill University Health Centre, McGill University, Montreal, Montreal, Quebec, Canada.
Cell Cycle (Georgetown, Tex.)
|December 31, 2019
Summary
Cyclin D1, a key cell cycle regulator, acts as an oncogene when deregulated, driving tumors. Recent research reveals its non-canonical functions and complex networks, offering new therapeutic targets.
Area of Science:
- Oncology
- Molecular Biology
- Cell Biology
Background:
- The cell cycle is regulated by cyclin-dependent kinases (CDKs) and cyclins.
- Cyclin D1, partnered with CDK4/6, senses mitogenic signals and controls cell cycle progression.
- Deregulation of cyclin D1 (overexpression, accumulation, abnormal localization) transforms it into an oncogene, driving various cancers.
Purpose of the Study:
- To review recent findings on the oncogenic roles of cyclin D1.
- To explore non-canonical functions of cyclin D1 influenced by its binding partners and cellular location.
- To highlight the potential of these insights for developing targeted therapies.
Main Methods:
- Review of recent scientific literature on cyclin D1.
- Analysis of data from mouse models of oncogenesis.
- Examination of proteomic and transcriptomic data identifying cyclin D1 networks.
Main Results:
- Cyclin D1 exhibits non-canonical functions beyond cell cycle regulation.
- These functions depend on cyclin D1's interaction partners and subcellular localization.
- Mouse models support these novel oncogenic roles.
- Proteomic and transcriptomic analyses reveal complex cyclin D1-associated networks.
Conclusions:
- Cyclin D1's pathophysiology involves non-canonical functions crucial for cancer development.
- Understanding these complex networks and interactions is vital for advancing targeted cancer therapies.
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