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Experimental Abdominal Sepsis: Sticking to an Awkward but Still Useful Translational Model
Federica Murando1, Andrea Peloso2,3, Lorenzo Cobianchi1,4
1General Surgery Department, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
Mediators of Inflammation
|December 31, 2019
Abstract:
Animal models are widely used to replicate human intra-abdominal infections. Different methodologies have been described and proposed in the scientific literature, including injection and surgical models. The aim of this review is to recapitulate the advantages and disadvantages of each method to help choose the most appropriate model for individual experimental purposes.
