Molecular imaging in the second near-infrared window

Area of Science:

• Biomedical Imaging
• Molecular Imaging
• Optical Engineering

Background:

• Significant advancements in fluorescence imaging within the second near-infrared (NIR-II) window have been observed over the past decade.
• NIR-II fluorescence imaging provides superior deep tissue penetration and high spatial-temporal resolution, crucial for physiological process profiling.
• Molecular imaging is a key technique for understanding biological activities at the molecular and cellular levels.

Purpose of the Study:

• To summarize recent achievements in NIR-II molecular imaging.
• To highlight strategies for designing effective NIR-II imaging probes.
• To provide guidance for the development of advanced NIR-II probes for high-performance molecular imaging.

Main Methods:

• Review and summarization of selected achievements in NIR-II molecular imaging.
• Analysis of rational design strategies for NIR-II imaging probes.
• Highlighting the applications of these probes in molecular imaging.

Main Results:

• Progress in NIR-II fluorescence imaging enhances molecular imaging capabilities.
• Rational probe design is key to optimizing NIR-II imaging performance.
• NIR-II molecular imaging provides more detailed and accurate biological information.

Conclusions:

• Extending molecular imaging into the NIR-II window significantly improves imaging performance.
• The report provides a framework for understanding NIR-II probe design and application.
• Future development of functional NIR-II probes will benefit from these insights for advanced molecular imaging.