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Related Concept Videos

Alzheimer's Disease: Overview01:26

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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
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Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
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Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
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Recent advances in understanding frontotemporal degeneration.

Barbara Borroni1, Alberto Benussi1

  • 1Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, 25100, Italy.

F1000Research
|December 31, 2019
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Summary

Frontotemporal degeneration (FTD) research advances diagnostics and treatments. New biomarkers and therapies offer hope for this rare neurodegenerative disorder.

Keywords:
TDP43Taubiomarkersdiagnosisfrontotemporal dementiatreatmenttrials

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Area of Science:

  • Neuroscience
  • Genetics
  • Clinical Neurology

Background:

  • Frontotemporal degeneration (FTD) is a complex group of neurodegenerative disorders with varied clinical, pathological, and genetic origins.
  • Recent years have seen significant progress in understanding FTD's clinical and biological facets.

Purpose of the Study:

  • To highlight key advancements and future directions in FTD research.
  • To emphasize the development of diagnostic and therapeutic strategies for FTD.

Main Methods:

  • Development of cerebrospinal fluid (CSF) and blood biomarkers.
  • Advancement of neuroimaging techniques.
  • Identification of disease modulators and early pharmacological treatments.

Main Results:

  • Emergence of new diagnostic and prognostic markers for proteinopathy identification and disease progression prediction.
  • Progress in identifying disease modulators and developing initial treatments for sporadic and genetic FTD.
  • Improved patient stratification for clinical trials and treatment response evaluation.

Conclusions:

  • Continued research promises deeper understanding of FTD.
  • Potential for a new era of disease-modifying therapies for FTD, addressing its current status as an orphan disorder.