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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Gene-Environment Interactions01:20

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Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
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Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
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Genomic Imprinting and Inheritance02:30

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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
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Inheritance of Chromatin Structures03:17

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Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
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Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization
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2019 environment, epigenetics and reproduction.

Michael K Skinner1

  • 1Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA 99164-4236, USA.

Environmental Epigenetics
|December 31, 2019
PubMed
Summary

This summary covers the 2018 Kenya Africa Conference on Environment, Epigenetics, and Reproduction. It highlights key discussions from a special issue focused on environmental epigenetics research.

Keywords:
Africaenvironmentepigeneticsreproduction

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Area of Science:

  • Environmental Science
  • Genetics
  • Reproductive Biology

Background:

  • The 2018 Kenya Africa Conference convened experts to discuss critical environmental and reproductive health issues.
  • Epigenetics, the study of heritable changes in gene expression, is increasingly recognized for its role in environmental health.

Purpose of the Study:

  • To summarize the proceedings of the fourth biannual Kenya Africa Conference.
  • To highlight the significance of environmental epigenetics research presented at the conference.

Main Methods:

  • Review of conference proceedings and discussions.
  • Analysis of papers published in a special issue on Environmental Epigenetics (Volume 5, Issues 3 and 4).

Main Results:

  • The conference provided a platform for interdisciplinary dialogue on environment, epigenetics, and reproduction.
  • A special issue showcased cutting-edge research in environmental epigenetics, addressing its impact on reproductive health.

Conclusions:

  • Environmental factors significantly influence epigenetic modifications, impacting reproductive outcomes.
  • Continued research in environmental epigenetics is crucial for understanding and mitigating health challenges in Africa.