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Updated: Jan 1, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

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Published on: July 14, 2023

Therapeutic Challenges for Elderly Patients with Primary Hyperparathyroidism.

Kenneth Sluis¹, Hyon Kim¹, Yuling He¹

¹Division of Endocrinology, Metabolism, and Nutrition, Department of Medicine, Rutgers University-Robert Wood Johnson Medical School, New Jersey, NJ 08903, USA.

Case Reports in Endocrinology

|December 31, 2019

Summary

Primary hyperparathyroidism (PHPT) management in octogenarians is challenging. Medical therapy offers a feasible and stable option for PHPT patients over 85 years old.

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Area of Science:

Endocrinology
Geriatric Medicine
Surgical Oncology

Background:

Primary hyperparathyroidism (PHPT) commonly affects older adults.
Parathyroidectomy offers cure but poses challenges in the elderly.
Aging populations necessitate evaluating PHPT treatment in octogenarians and nonagenarians.

Observation:

A case series reviewed eight patients aged 85+ with PHPT.
Average follow-up was 5.6 years.
Six patients received medical management; two underwent parathyroid resection.

Findings:

Most medically managed PHPT patients showed long-term disease stability (>5 years).
Two patients who underwent parathyroid resection also had stable disease.
No clear consensus guidelines exist for treating PHPT in patients over 85.

Implications:

Medical therapy is a viable treatment option for PHPT in patients over 85.
Further research is needed to establish definitive treatment guidelines for this demographic.
Individualized treatment approaches are crucial for elderly PHPT patients.