Characterization of an Electronic Corneal Prosthesis System

Area of Science:

• Ophthalmology
• Biomedical Engineering
• Materials Science

Background:

• Corneal opacity is a primary cause of reversible blindness globally.
• Current treatments focus on corneal clarity, which is not always achievable.
• Novel approaches are needed to restore vision in cases of intractable corneal disease.

Purpose of the Study:

• To develop and characterize a functional electronic corneal prosthesis (intraocular projector).
• To assess the feasibility of restoring high-quality vision without requiring corneal clarity.

Main Methods:

• Four intraocular projection systems were fabricated using commercial electronic components and biocompatible materials.
• Systems were evaluated for optical performance, biocompatibility, thermal properties, waterproofing, and durability under accelerated wear.
• A surgical implantation technique was developed and demonstrated on a cadaver eye.

Main Results:

• The intraocular projectors were sized for intraocular implantation and achieved better than 20/200 visual acuity.
• In vitro testing confirmed no cytotoxicity. Devices exhibited minimal temperature increase (<2°C) and operated for over 12 weeks under accelerated wear.
• Successful implantation was demonstrated via corneal trephination in a cadaver model.

Conclusions:

• This study presents the first fully functional intraocular projection systems.
• This technology holds significant potential as a new therapeutic option for intractable corneal blindness.