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The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
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Aging01:26

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Updated: Dec 31, 2025

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
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Molecular Connections Between Circadian Clocks and Aging.

Patrick-Simon Welz1, S A Benitah2

  • 1Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.

Journal of Molecular Biology
|December 31, 2019
PubMed
Summary

Aging impairs the mammalian circadian clock, disrupting sleep and tissue synchronization. This decline accelerates aging, highlighting the intertwined relationship between circadian rhythms and aging processes.

Keywords:
circadian reprogramingderegulated nutrient sensingmitochondrial dysfunctionstem cell exhaustiontissue homeostasis

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Area of Science:

  • Chronobiology
  • Gerontology
  • Molecular Biology

Background:

  • The mammalian circadian clock synchronizes behavior and physiology with daily environmental changes.
  • Proper circadian clock function is vital for maintaining cellular and tissue homeostasis.
  • Aging compromises circadian clock robustness, affecting sleep, tissue synchronization, and molecular rhythms.

Purpose of the Study:

  • To review the impact of aging on the circadian clock.
  • To examine how circadian clock decline influences the aging process.
  • To explore the molecular interplay between aging and circadian machinery.

Main Methods:

  • Literature review of current knowledge on circadian rhythms and aging.
  • Analysis of studies investigating age-related changes in circadian clock function.
  • Synthesis of research on the molecular links between aging and circadian processes.

Main Results:

  • Aging reduces circadian clock robustness, leading to disrupted sleep-wake cycles.
  • Peripheral tissue circadian rhythms lose synchrony with age.
  • Molecular output of the circadian clock is reprogrammed during aging.

Conclusions:

  • The circadian clock's functional decline exacerbates aging.
  • Aging and circadian clock dysfunction create a detrimental feedback loop.
  • Understanding this interplay is crucial for addressing age-related decline.