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Proteins, peptides and peptidomimetics as active agents in implant surface functionalization
Przemysław Jurczak1, Julia Witkowska1, Sylwia Rodziewicz-Motowidło1
1Department of Biomedical Chemistry, Faculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, Poland.
Advances in Colloid and Interface Science
|December 31, 2019
Summary
Advancements in implant surface modifications are crucial for improving bone-implant integration. Chemical methods using proteins, peptides, and peptidomimetics show promise for enhancing titanium implant coatings and long-term usability.
Area of Science:
- Biomaterials Science
- Orthopedic Surgery
- Surface Chemistry
Background:
- Implants significantly enhance human life quality, with major advancements in materials and structure over two decades.
- The complexity of the bone-implant interface was underestimated, becoming a key challenge for long-term implant success.
- Focus has shifted to the bone-implant interface as the critical factor for implant longevity.
Purpose of the Study:
- To review recent progress in implant surface modification techniques.
- To highlight the importance of chemical approaches for enhancing osseointegration.
- To discuss the potential of proteins, peptides, and peptidomimetics for titanium surface coatings.
Main Methods:
- Literature review of recent advancements in implant surface modification.
- Emphasis on chemical modification strategies.
- Focus on the application of biomolecules for surface functionalization.
Main Results:
- Surface modifications are critical for improving the bone-implant interface.
- Chemical methods offer promising strategies for enhancing osseointegration.
- Proteins, peptides, and peptidomimetics are effective agents for titanium surface coatings.
Conclusions:
- Optimizing the bone-implant interface is key to increasing implant long-term usability.
- Chemical surface modifications, particularly using biomolecules, represent a promising direction.
- Further research into protein, peptide, and peptidomimetic coatings can advance implant technology.
