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Updated: Dec 31, 2025

In Vivo Immunogenicity Screening of Tumor-Derived Extracellular Vesicles by Flow Cytometry of Splenic T Cells
Published on: September 23, 2021
Small Particles, Big Effects: The Interplay Between Exosomes and Dendritic Cells in Antitumor Immunity and
Bruno Deltreggia Benites1, Marisa Claudia Alvarez1, Sara Teresinha Olalla Saad1
1Hematology and Transfusion Medicine Center, University of Campinas, Campinas 13083-970, Brazil.
Abstract:
Dendritic cells play a fundamental role in the antitumor immunity cycle, and the loss of their antigen-presenting function is a recognized mechanism of tumor evasion. We have recently demonstrated the effect of exosomes extracted from serum of patients with acute myeloid leukemia as important inducers of dendritic cell immunotolerance, and several other works have recently demonstrated the effects of these nanoparticles on immunity to other tumor types as well. The aim of this review was to highlight the recent findings on the effects of tumor exosomes on dendritic cell functions, the mechanisms by which they can lead to tumor evasion, and their manipulation as a possible strategy in cancer treatment.
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