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Related Concept Videos

Complement System01:27

Complement System

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The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
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The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
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Related Experiment Video

Updated: Dec 31, 2025

In Vitro Methods for Comparing Target Binding and CDC Induction Between Therapeutic Antibodies: Applications in Biosimilarity Analysis
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Complement and Complement Targeting Therapies in Glomerular Diseases.

Sofia Andrighetto1,2, Jeremy Leventhal1, Gianluigi Zaza2

  • 1Department of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, 1 Levy Place, New York, NY 10029, USA.

International Journal of Molecular Sciences
|January 1, 2020
PubMed
Summary

The complement cascade, a key part of innate immunity, plays a significant role in various kidney diseases. Targeting complement activation offers a promising therapeutic strategy for these conditions.

Keywords:
C3 glomerulopathyalternative complement pathwaycomplementcomplement-targeting therapiesfocal segmental glomerulosclerosishemolytic uremic syndrome

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Area of Science:

  • Immunology
  • Nephrology
  • Pathophysiology

Background:

  • The complement cascade is integral to the innate immune system, defending against pathogens.
  • Emerging evidence implicates complement in the pathogenesis of diverse renal diseases, including antibody-related glomerulopathies and non-antibody-mediated kidney diseases like C3 glomerulopathy and atypical hemolytic uremic syndrome.
  • Its pivotal role in renal pathogenesis highlights complement activation as a viable therapeutic target.

Purpose of the Study:

  • To review complement activation and regulation pathways.
  • To illustrate the role of complement in initiating and exacerbating glomerular injury.
  • To discuss novel complement-targeting therapies for kidney diseases.

Main Methods:

  • Review of scientific literature on complement pathways.
  • Analysis of complement's role in glomerular injury mechanisms.
  • Evaluation of current and emerging anti-complement therapeutic agents.

Main Results:

  • Complement activation contributes to a wide range of kidney diseases.
  • Several anti-complement agents are approved or in development.
  • Targeting complement pathways shows therapeutic potential.

Conclusions:

  • The complement system is a critical factor in renal disease pathogenesis.
  • Therapeutic strategies targeting complement activation are advancing rapidly.
  • Novel anti-complement agents represent a promising frontier in treating kidney diseases.