Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Particulate contamination in spinal analgesia.

S Eriksen1

  • 1Department of Anaesthesia, Haderslev Sygehus, Denmark.

Acta Anaesthesiologica Scandinavica
|October 1, 1988
PubMed
Summary

Particulate contamination in bupivacaine injectates was investigated. Bacterial filters significantly increased contamination, suggesting their clinical use in spinal analgesia is questionable.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification of strategies to optimize pain management in people with dementia living in nursing homes using nominal group technique.

Geriatric nursing (New York, N.Y.)·2026
Same author

Dropout from farm-based day care for people with dementia in Norway: a follow-up study.

BMC geriatrics·2020
Same author

The validity of the hospital anxiety and depression scale and the geriatric depression scale-5 in home-dwelling old adults in Norway<sup>✰</sup>.

Journal of affective disorders·2019
Same author

Alcohol as a gender symbol.

Scandinavian journal of history·2012
Same author

The effect of trimethyltin on acetylcholine release in the guinea-pig trachea.

Environmental toxicology and pharmacology·2011
Same author

Enhancement of acetylcholine release by homoanatoxin-a from Oscillatoria formosa.

Environmental toxicology and pharmacology·2011

Area of Science:

  • Anesthesiology
  • Materials Science

Background:

  • Particulate contamination in injectable medications can pose risks.
  • Ensuring the purity of spinal analgesia injectates is critical for patient safety.

Purpose of the Study:

  • To quantify particulate contamination in bupivacaine 0.5% for spinal analgesia.
  • To evaluate the impact of different preparation methods and filtration on contamination levels.

Main Methods:

  • Microscopic investigation of bupivacaine injectates.
  • Comparison of particulate load using glass vs. plastic syringes.
  • Assessment of contamination after vial opening techniques and bacterial filter use.

Main Results:

  • No significant difference in particulate contamination was found between glass and plastic syringes.
  • Different vial opening techniques did not alter contamination levels.
  • Use of bacterial filters led to a significant increase in particulate contamination, likely due to filter debris.

Conclusions:

  • Standard preparation methods for bupivacaine injectates do not introduce significant particulate contamination.
  • Commercially available bacterial filters are associated with increased particulate contamination in spinal analgesia preparations.
  • The routine clinical use of bacterial filters for spinal analgesia injectates is questionable and warrants reconsideration.

Related Experiment Videos