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Coagulatory Defects in Type-1 and Type-2 Diabetes
Amélie I S Sobczak1, Alan J Stewart1
1Medical and Biological Sciences Building, School of Medicine, University of St Andrews, St Andrews KY16 9TF, UK.
International Journal of Molecular Sciences
|January 1, 2020
Summary
Diabetes significantly increases cardiovascular disease risk by altering blood clotting (haemostasis) through mechanisms differing between type-1 and type-2 diabetes.
Area of Science:
- Endocrinology
- Cardiovascular Medicine
- Hematology
Background:
- Diabetes mellitus (type-1 and type-2) is a global health concern.
- Cardiovascular diseases are a leading cause of mortality in diabetic patients.
- Diabetes-induced physiological changes significantly impact haemostasis.
Purpose of the Study:
- To review the mechanisms linking diabetes to coagulatory disorders.
- To differentiate these mechanisms between type-1 and type-2 diabetes.
Main Methods:
- Literature review of studies on diabetes and haemostasis.
- Analysis of physiological changes affecting blood coagulation in diabetes.
Main Results:
- Diabetes alters coagulatory protein concentrations and platelet activation.
- Metabolic changes, including lipotoxicity and atherosclerosis, contribute to coagulopathy.
- Endothelial dysfunction and pro-coagulatory microparticles are implicated.
Conclusions:
- Diabetes confers an elevated risk of thrombotic events.
- Specific haemostatic alterations vary between type-1 and type-2 diabetes, necessitating tailored management strategies.
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