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Association between chymase gene polymorphisms and atrial fibrillation in Chinese Han population

Dongchen Zhou1, Yuewei Chen1, Jiaxin Wu1

  • 1Department of Cardiology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

BMC Cardiovascular Disorders
|January 1, 2020
PubMed

Insights

Genetic variations in the chymase 1 gene (CMA1) are linked to atrial fibrillation (AF) risk. The rs1800875 GG genotype may increase susceptibility to AF in the Chinese Han population.

Area of Science:

  • Cardiovascular Genetics
  • Molecular Cardiology
  • Genetic Epidemiology

Background:

  • Chymase is a key enzyme in angiotensin II formation within cardiovascular tissues, influencing atrial remodeling.
  • This study investigates the genetic underpinnings of atrial fibrillation (AF) in relation to chymase 1 gene (CMA1) polymorphisms.

Purpose of the Study:

  • To examine the association between specific CMA1 gene polymorphisms and the risk of developing atrial fibrillation (AF).
  • To identify potential genetic susceptibility factors for AF in the Chinese Han population.

Main Methods:

  • A case-control study design was employed, including 126 lone AF patients and 120 healthy controls from the Chinese Han population.
  • Genotyping was performed for five distinct CMA1 polymorphisms.

Main Results:

  • The CMA1 polymorphism rs1800875 (G-1903A) showed a significant association with AF.
  • A higher frequency of the GG genotype at rs1800875 was observed in AF patients compared to controls (p=0.009).
  • Haplotype analysis indicated that the rs1800875-G haplotype increased AF risk (OR=1.668), while the rs1800875-A haplotype decreased risk (OR=0.178).

Conclusions:

  • CMA1 gene polymorphisms may play a role in the pathogenesis of atrial fibrillation.
  • The rs1800875 GG genotype is suggested as a potential susceptibility factor for AF in the Chinese Han population.
Abstract

Keywords:
Angiotensin IIAtrial fibrillationCMA1ChymaseSingle nucleotide polymorphism

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