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Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

1.8K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
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Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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Development of Immunocompetence01:22

Development of Immunocompetence

702
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
702
Tumor Immunotherapy01:27

Tumor Immunotherapy

1.7K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.7K
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

2.8K
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
2.8K
Autoimmune Disorders01:29

Autoimmune Disorders

1.4K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Updated: Dec 31, 2025

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
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Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

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Personalized therapy for common variable immunodeficiency.

Francisco A Bonilla

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    Advances in understanding common variable immunodeficiency (CVID) are improving treatments. Genetic insights are enabling targeted therapies for some patients, with more expected soon.

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    Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
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    Transduction and Expansion of Primary T Cells in Nine Days with Maintenance of Central Memory Phenotype
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    Area of Science:

    • Immunology
    • Genetics
    • Medical Diagnostics

    Background:

    • Common variable immunodeficiency (CVID) is a clinical diagnosis from the 1970s.
    • Pathophysiology is understood in only 25% of CVID patients, despite advances in immunology and genetics.
    • Recent progress allows for more specific, individualized therapies.

    Purpose of the Study:

    • To review current understanding and treatment of CVID.
    • To highlight recent advances in pathophysiology and targeted therapies.
    • To discuss future directions in CVID management.

    Main Methods:

    • Literature review.
    • Author's clinical experience.

    Main Results:

    • Immunoglobulin therapy has been standard for over 50 years, with various products and administration routes.
    • Stem cell therapy is increasingly viable for severe immune dysregulation in CVID.
    • Genetic and molecular understanding enables targeted therapies (small molecules, biologics) for specific CVID subtypes.

    Conclusions:

    • Further research into CVID pathophysiology will drive new targeted treatments.
    • Development of biologics and small-molecule immune modulators will expand therapeutic options.
    • Future CVID management will likely involve more personalized and precise interventions.