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Elastosis in meningioma. A case report and electron microscopic study
S Akagi1, K Mizobuchi, K Taguchi
1Department of Pathology, Okayama University Hospital, Japan.
Abstract:
A 55-year-old man underwent left frontoparietal craniotomy for total removal of a parasagittal meningioma. The tumor showed a predominant pattern of meningotheliomatous meningioma and a partial pattern of angiomatous, transitional and fibrous meningioma. A striking feature was the appearance of unusually numerous elastinophilic material in the intercellular stroma. We observed a process in which the progress of elastosis changed the appearance of meningotheliomatous meningioma to a hypocellular, and subsequently acellular fibroelastotic node. Three years after the first craniotomy, meningioma recurred at the same site. The recurrent tumor also showed the histological pattern of meningotheliomatous meningioma with stromal elastosis, as previously observed. This is the first report of a case of meningioma with stromal elastosis. The present case represents the first unequivocal demonstration of elastogenesis in meningioma.
Insights
This study reports the first case of meningioma with stromal elastosis, a condition where elastinophilic material accumulates in the tumor stroma. The observed elastogenesis transformed the meningioma, highlighting a novel aspect of meningioma progression.
Area of Science:
- Neuro-oncology
- Pathology
- Histology
Background:
- Meningiomas are tumors arising from the meninges.
- Meningotheliomatous meningioma is a common subtype.
- Stromal composition is crucial for understanding tumor behavior.
Observation:
- A parasagittal meningioma exhibited abundant elastinophilic material in its intercellular stroma.
- This stromal elastosis led to a transformation into a fibroelastotic node.
- Recurrence of the meningioma showed similar histological features, including stromal elastosis.
Findings:
- This case presents the first documented instance of meningioma with stromal elastosis.
- Unequivocal evidence of elastogenesis was demonstrated within the meningioma.
- The process altered the typical histological appearance of meningotheliomatous meningioma.
Implications:
- Stromal elastosis may represent a novel pathway in meningioma development or progression.
- Understanding elastogenesis could offer new insights into meningioma pathogenesis.
- Further research is warranted to explore the clinical significance of stromal elastosis in meningiomas.