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Cyclic nucleotides, gut physiology and inflammation

Hari Prasad1, Avinash Ravindranath Shenoy2, Sandhya Srikant Visweswariah1

  • 1Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bengaluru, India.

The FEBS Journal
|January 1, 2020
PubMed

Insights

Pathogenic bacteria cause diarrhea by disrupting gut ion and water secretion via cyclic adenosine 3

Area of Science:

  • Gastroenterology
  • Microbiology
  • Cellular Biology

Background:

  • Diarrheal disease is a major global health concern, particularly in children.
  • Gut barrier erosion and inflammation are secondary effects of diarrhea.
  • Pathogenic bacteria contribute significantly to diarrheal diseases.

Purpose of the Study:

  • To investigate the role of cyclic nucleotides in pathogenic bacteria-mediated diarrhea.
  • To explore the impact of ion and water secretion on gut homeostasis.
  • To examine the potential modulation of inflammasome signaling by ion flux.

Main Methods:

  • Focus on pathogenic bacteria-mediated diarrhea.
  • Emphasis on cyclic adenosine 3',5'-monophosphate (cAMP) and cyclic guanosine 3',5'-monophosphate (cGMP) signaling pathways.
  • Speculation on ion flux effects on inflammasome signaling.

Main Results:

  • Cyclic nucleotides (cAMP and cGMP) drive signaling outputs leading to gut epithelial ion and water secretion.
  • Aberrant ion efflux and influx are implicated in diarrhea.
  • Potential modulation of inflammasome signaling by ion transport.

Conclusions:

  • Understanding cyclic nucleotide signaling is crucial for addressing bacterial diarrhea.
  • Ion transport dysregulation impacts gut barrier integrity and function.
  • Further research into ion flux and inflammasome interactions is warranted.

Keywords:
cAMPcGMPcholera toxininflammasomereceptor guanylyl cyclase Csalmonellosis

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