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Evaluation of monocyte to high-density lipoprotein ratio, lymphocytes, monocytes, and platelets in psoriasis
Ezgi Aktaş Karabay1, Damla Demir2, Aslı Aksu Çerman2
1Department of Dermatology and Venereology, Faculty of Medicine, Bahçeşehir University, İstanbul, Turkey.
Insights
Inflammatory markers like C-reactive protein and various ratios were elevated in psoriasis patients, correlating with disease severity. These markers may aid in monitoring psoriasis and detecting associated cardiovascular risks.
Area of Science:
- Dermatology
- Immunology
- Cardiovascular Medicine
Background:
- Psoriasis is a chronic inflammatory skin disease linked to cardiovascular issues.
- Identifying reliable inflammatory markers is crucial for managing psoriasis and its comorbidities.
Purpose of the Study:
- To evaluate C-reactive protein (CRP), monocyte-to-high-density lipoprotein ratio (MHR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) as inflammatory markers in psoriasis.
- To investigate the correlation between these inflammatory markers and psoriasis severity, assessed by the Psoriasis Area and Severity Index (PASI).
Main Methods:
- A retrospective analysis comparing 94 psoriasis patients with 118 healthy controls.
- Evaluation of CRP, MHR, NLR, PLR, and MLR values in both groups.
Main Results:
- Significant differences in CRP, MHR, NLR, and MLR were found between psoriasis patients and controls (p<0.05).
- Positive correlations were observed between PASI and CRP, MHR, NLR, PLR, and MLR (p<0.05).
Conclusions:
- Elevated CRP, MHR, NLR, and MLR are significantly associated with psoriasis.
- MHR may serve as a reliable marker for monitoring psoriasis, potentially aiding in early detection of cardiovascular comorbidities.
Background:
Psoriasis is a chronic immune-mediated inflammatory skin disease that is associated with cardiovascular comorbidities.
Objectives:
The objective of this retrospective study is to assess the C-reactive protein, monocyte-to-high-density-lipoprotein ratio, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio as inflammatory markers in patients with psoriasis and to search for a relationship between these parameters and psoriasis severity, as defined by the psoriasis area and severity index.
Methods:
There were 94 patients with psoriasis and 118 healthy controls enrolled in the study. The C-reactive protein, monocyte-to-high-density-lipoprotein ratio, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio values of two groups were retrospectively evaluated.
Results:
Statistically significant differences were observed in terms of C-reactive protein, monocyte-to-high-density-lipoprotein ratio, neutrophil-to-lymphocyte ratio and monocyte-to-lymphocyte ratio between the patient and control groups (p=0.001, p=0.003, p=0.038, and p=0.007, respectively). Positive correlations were found between the psoriasis area and severity index and the values of C-reactive protein, monocyte-to-high-density-lipoprotein ratio, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio (r: 0.381; p<0.01, r: 0.203; p<0.05, r: 0.268; p<0.01, r: 0.374; p<0.01, r: 0.294; p<0.01, respectively).
Study Limitations:
The small sample size and the retrospective design of the study are limitations.
Conclusion:
Elevated C-reactive protein, monocyte-to-high-density-lipoprotein ratio, neutrophil-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio were significantly associated with psoriasis. A positive correlation between C-reactive protein and monocyte-to-high-density-lipoprotein ratio leads to the suggestion that monocyte-to-high-density-lipoprotein ratio might be a reliable parameter in psoriasis during the follow-up. The relationship between the diasease and inflammatory parameters might provide early detection of cardiovascular morbidities in psoriasis patients.
