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Parathyroid gland weight is associated with high density lipoprotein levels in patients with primary
Aseel Al Dayyeni1,2, Amar Mahdi3, Yuling He1
1Divisions of Endocrinology, Departments of Medicine, Rutgers University-Robert Wood Johnson Medical School, New Brunswick, NJ, United States.
Objective:
To investigate the relationship between parathyroid gland weight and high-density lipoprotein (HDL) levels in patients with primary hyperparathyroidism (PHPT).
Methods:
In this retrospective case control study, we reviewed 329 PHPT patients aged from 20 to 85 years who had a parathyroidectomy at Robert Wood Johnson University Hospital. The patients were divided into 5 quintiles according to their parathyroid gland weight: 68 patients had a parathyroid gland weight <0.3 g, 66 patients had a gland weight 0.3-0.45 g, 67 patients had a gland weight 0.45-0.7 g, 63 patients had a gland weight 0.7-1.25 g, and 65 patients had a gland weight ≥1.25 g.
Results:
Body Mass Index (BMI) trended to be higher across the quintiles of parathyroid gland weight (P = 0.003). Serum calcium and PTH levels were significantly increased across parathyroid gland quintiles (p < 0.0001). HDL levels tended to be lower across the increasing quintiles of parathyroid gland weight (P = 0.01). There was a negative relationship between log parathyroid gland weight and HDL in patients with PHPT in a simple linear regression (r = -0.160, P = 0.003). The negative association remained significant after adjustment for age and BMI (r = -0.114, P = 0.039). Furthermore, parathyroid gland weight was significantly associated with levels of triglyceride (r = 0.126, P = 0.02), but this relationship lost its significance after adjustment for age and BMI (r = 0.082, P ˃ 0.05).
Conclusions:
PHPT patients with heavier parathyroid glands tended to have higher BMI and lower HDL levels.
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