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Updated: Dec 31, 2025

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
Functionalized Magnetic Nanoparticles as Catalysts for Enantioselective Henry Reaction
Carla Sappino1, Ludovica Primitivo1, Martina De Angelis1
1Dip. Chimica, Sapienza Università di Roma, p.le A. Moro 5, 00185 Rome, Italy.
Abstract:
With the aim to easily recover and reuse the catalyst, an efficient amino alcohol catalyst previously tested in the asymmetric addition of diethylzinc to several aromatic aldehydes has been immobilized on proper functionalized superparamagnetic core-shell magnetite-silica nanoparticles and employed in the Henry reaction in the semi-homogeneous phase. The nanocatalyst exhibits a promising catalytic activity that remains unchanged in the three catalytic cycles performed. The results prove that highly efficient catalysts, by being immobilized on suitable magnetic nanosupports, can be easily recovered and reused, maintaining their catalytic behavior.
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