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Updated: Dec 31, 2025
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Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
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Cross-talk between Myc and p53 in B-cell lymphomas
Li Yu1,2, Tian-Tian Yu1, Ken H Young2,3
1Department of Hematology, The Second Affiliated Hospital to Nanchang University, Nanchang, Jiangxi 330006, China.
Chronic Diseases and Translational Medicine
|January 1, 2020
Summary
Myc and p53 proteins are crucial in lymphoma development and progression. Targeting these proteins shows promise for new therapies, despite current challenges with drug resistance in B-cell lymphomas.
Area of Science:
- Oncology
- Molecular Biology
- Immunology
Background:
- Myc and p53 proteins regulate vital cellular functions, including immune response and lymphocyte survival.
- These proteins are expressed in lymphoid organs, key sites for B-cell malignancy development and activation.
Purpose of the Study:
- To review the physiological and pathological roles of Myc and p53 proteins in lymphoid neoplasms.
- To explore the interplay between Myc and p53 and its impact on B-cell lymphoma prognosis.
- To highlight recent clinical trials targeting Myc and p53 pathways for lymphoma treatment.
Main Methods:
- Literature review of physiological and pathological roles of Myc and p53.
- Analysis of genetic alterations and mechanisms contributing to lymphoma development.
- Review of clinical trials for novel agents targeting Myc and/or p53 signaling pathways.
Main Results:
- Constitutive activation, rearrangement, or mutation of MYC and TP53 drive lymphoma development, progression, and therapy resistance.
- Cross-talk between Myc and p53 negatively impacts prognosis in various B-cell lymphomas.
- Clinical trials targeting Myc/p53 pathways show potential but face challenges with drug resistance.
Conclusions:
- Understanding Myc, p53, and their cross-talk is vital for B-cell lymphoma pathogenesis.
- Targeting Myc and p53 offers therapeutic opportunities, necessitating strategies to overcome drug resistance.
- Optimizing novel therapeutic approaches by targeting diverse mechanisms is key to eradicating lymphoma cells.
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