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Relation between ureteral telocytes and the hydronephrosis development in children
Michał Wolnicki1, Veronika Aleksandrovych2, Anna Gil2
1Department of Pediatric Urology, Jagiellonian University Medical College, Kraków, Poland.
Folia Medica Cracoviensia
|January 1, 2020
Summary
Telocytes, important mesenchymal cells, decrease in density during pediatric hydronephrosis development. Their reduced presence and increased mast cells indicate inflammation and fibrosis, differing based on obstruction or crossing renal vessels.
Area of Science:
- Pediatric Urology
- Cell Biology
- Pathophysiology
Background:
- Hydronephrosis is a significant pediatric urological issue.
- Mesenchymal cells, including telocytes, are implicated in fibrosis and hydronephrosis.
- The role of telocytes in human ureters concerning hydronephrosis requires elucidation.
Purpose of the Study:
- To identify telocytes in the human ureter.
- To investigate the association between telocyte density and hydronephrosis.
- To explore the potential role of telocytes in the pathophysiology of pediatric hydronephrosis.
Main Methods:
- Tissue samples from 18 hydronephrosis patients and 10 controls were analyzed.
- Immunohistochemistry was used to detect telocytes (c-kit, PDGFRα) and mast cells (tryptase).
- Histology assessed tissue morphology, collagen, and mast cell presence.
Main Results:
- Telocytes were identified in the ureteral wall.
- Hydronephrosis patients showed decreased telocyte density, increased collagen, and more mast cells.
- Ureters with crossing renal vessels had more telocytes than those with obstruction.
Conclusions:
- Declining telocyte density correlates with hydronephrosis development.
- Increased mast cells suggest local inflammation in the ureteral wall.
- Differences in telocyte density and collagen suggest distinct pathophysiological roles for obstruction versus crossing renal vessels in hydronephrosis.
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