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Measurement of BK-polyomavirus Non-Coding Control Region Driven Transcriptional Activity Via Flow Cytometry
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BK polyomavirus-pathogen, paradigm and puzzle.

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  • 1Department of Internal Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|January 1, 2020
PubMed
Summary
This summary is machine-generated.

BK virus, a common polyomavirus, can cause serious kidney issues in transplant recipients. Management focuses on reducing immunosuppression, but graft failure remains a concern, highlighting the need for better diagnostics and treatments.

Keywords:
BK virus pathogenesisdiagnosisprevention and treatment and re-transplantationrisk factorsscreening

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Area of Science:

  • Nephrology
  • Virology
  • Immunology

Background:

  • BK virus (BKV) is a polyomavirus with high adult seroprevalence, typically acquired in childhood.
  • BKV remains latent until immune suppression, often reactivating in organ transplant recipients.
  • BKV infection can lead to significant complications, including BK polyomavirus nephropathy (BKVAN) and graft failure.

Purpose of the Study:

  • To review the clinical spectrum and outcomes of BK virus infection in transplant patients.
  • To discuss current diagnostic and treatment strategies for BK virus-associated nephropathy.
  • To highlight areas for future research in BK virus management.

Main Methods:

  • Literature review of BK virus in the context of transplantation.
  • Analysis of clinical presentations, diagnostic methods, and treatment outcomes.
  • Discussion of emerging diagnostic tools and therapeutic approaches.

Main Results:

  • BK polyomavirus nephropathy affects 5-10% of renal transplant recipients, with 50-80% of these progressing to graft failure.
  • BKV is associated with BKVAN, ureteral stenosis, hemorrhagic cystitis, and certain carcinomas.
  • Current treatment involves reducing immunosuppression, which carries a risk of graft rejection.

Conclusions:

  • BK virus poses a significant threat to renal allograft survival, necessitating careful monitoring in transplant patients.
  • Noninvasive diagnostic methods are under investigation to improve early detection.
  • Optimizing immunosuppression and achieving viral clearance are crucial for successful repeat transplantation.