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Updated: Dec 31, 2025

Synthesis and Purification of Iodoaziridines Involving Quantitative Selection of the Optimal Stationary Phase for Chromatography
Published on: May 16, 2014
Imidazolium ionic liquids-derived carbon dots-modified silica stationary phase for hydrophilic interaction
Lijun Song1, Haijuan Zhang2, Jia Chen2
1CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, China; Laboratory on Pollution Monitoring and Control, College of Chemistry and Chemical Engineering, Xinjiang Normal University, Urumqi, 830054, China.
Abstract:
In this study, imidazolium ionic liquids-derived carbon dots (ImCDs) were successfully synthesized and bonded on the surface of spherical porous silica as a new stationary phase (Sil-ImCDs) for hydrophilic interaction chromatography (HILIC). First, the ImCDs were synthesized by the reaction of amino ionic liquids with citric acid, and then they were grafted onto the surface of aminopropyl-modified silica. A series of characterizations including infrared spectra, elemental analysis and laser confocal microscope proved that the preparation was successful. It was found that the Sil-ImCDs had good separation efficiency in the separation of bases, nucleosides, amino acids, saccharides and ginsenosides. It is interesting that we found that Sil-ImCDs has better hydrophilic chromatographic performance compared with methylimidazole-modified silica and aminopropyl-modified silica. It may be due to the rich functional group which is available after the formation of carbon dots from imidazolium ionic liquids and citric acid.
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