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Phosphorylation Signaling in APP Processing in Alzheimer's Disease
Tao Zhang1, Dongmei Chen1, Tae Ho Lee1
1Fujian Key Laboratory for Translational Research in Cancer and Neurodegenerative Diseases, Institute for Translational Medicine, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350122, China.
International Journal of Molecular Sciences
|January 2, 2020
Summary
Phosphorylation of amyloid precursor protein (APP) and its processing enzymes influences amyloid-beta (Aβ) accumulation in Alzheimer's disease (AD). Targeting these phosphorylation pathways offers potential therapeutic strategies for AD.
Area of Science:
- Neuroscience
- Biochemistry
- Molecular Biology
Background:
- Alzheimer's disease (AD) is characterized by abnormal amyloid-beta (Aβ) accumulation in the central nervous system.
- Amyloid precursor protein (APP) processing is crucial for Aβ generation.
- Phosphorylation of APP and secretases regulates Aβ production and APP function.
Purpose of the Study:
- To review kinases and signaling pathways involved in APP and secretase phosphorylation.
- To explore how phosphorylation affects APP processing and Aβ pathology.
- To discuss therapeutic potential of modulating these pathways for AD.
Main Methods:
- Literature review of studies on APP phosphorylation and Alzheimer's disease.
- Analysis of signaling pathways regulating secretase activity.
- Examination of the impact of phosphorylation on APP processing.
Main Results:
- Phosphorylation critically modulates APP processing by affecting APP localization and secretase activity.
- Specific kinases and signaling pathways are identified as key regulators.
- Altered phosphorylation impacts Aβ generation and overall AD pathology.
Conclusions:
- Modulating APP and secretase phosphorylation is a promising therapeutic avenue for Alzheimer's disease.
- Understanding these phosphorylation-dependent mechanisms is vital for developing novel AD interventions.
- Targeting specific kinases offers a potential strategy to reduce Aβ pathology.
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