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The FSHR Expression in Head and Neck Squamous Cell Cancer. A Pilot Immunohistochemical Study
Tomas Olejar1,2, David Vetvicka3, Jan Boucek4
1Institute of Biophysics and Informatics, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
Background/Aim:
Follicle-stimulating hormone receptor (FSHr), expressed on endothelial cells of vessels in different malignant tumors, has been recently investigated as a potential pan-receptor of cancer treatment. However, the expression of this receptor has also been confirmed in other tissues under pathological conditions including cancer. The aim of the presented pilot study was to evaluate the expression of FSHr in head and neck squamous cancer (HNSCC).
Patients And Methods:
A total of 28 HNSCC patient samples were immunohistochemically analyzed for the presence of FSHr using a commercially available primary antibody.
Results:
FSHr was detected not only in the tumor tissue, but also in the basal layer or dysplastic parts of squamous mucosa and also in fibroblasts surrounding the tumor tissue.
Conclusion:
FSHr is present on different benign or malignant mesenchymal and epithelial structures in HNSCC. A brief literature review revealed a wider role of FSHr in the development of neoplasia.
Insights
Follicle-stimulating hormone receptor (FSHr) is present in head and neck squamous cell carcinoma (HNSCC) tissues, including surrounding cells. This finding suggests FSHr may play a role in cancer development.
Area of Science:
- Oncology
- Molecular Biology
- Endocrinology
Background:
- Follicle-stimulating hormone receptor (FSHr) is a potential pan-cancer target.
- FSHr expression is observed in various malignant tumors and pathological tissues.
- Its role in head and neck squamous cell carcinoma (HNSCC) requires further investigation.
Purpose of the Study:
- To evaluate the expression of FSHr in HNSCC.
- To determine the presence of FSHr in tumor and surrounding tissues.
Main Methods:
- Immunohistochemical analysis of 28 HNSCC patient samples.
- Utilized a commercially available primary antibody for FSHr detection.
Main Results:
- FSHr was detected in HNSCC tumor tissue.
- FSHr expression was also found in the basal layer and dysplastic squamous mucosa.
- Fibroblasts surrounding the tumor tissue also showed FSHr presence.
Conclusions:
- FSHr is expressed in both benign and malignant mesenchymal and epithelial structures within HNSCC.
- FSHr may have a broader role in the development of neoplasia.
- Further research into FSHr's role in cancer development is warranted.
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