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Related Concept Videos

Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

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The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
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At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
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Characterising the urinary excretion of thymidine dimer photolesions in mice.

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology·2026
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Skin lesion triage in organ transplant recipients using line-field confocal optical coherence tomography: a retrospective classification study.

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[Porphyria cutanea tarda].

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Updated: Dec 31, 2025

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
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Improving Photoprotection and Implications for 25(OH)D Formation.

Hans Christian Wulf1, Peter Alshede Philipsen2

  • 1Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark h.wulf@regionh.dk.

Anticancer Research
|January 2, 2020
PubMed
Summary

Using sunscreen with two applications before sun exposure effectively prevents sunburn and maintains vitamin D (25(OH)D) levels, even after a week-long vacation.

Keywords:
25(OH)DSunscreenUVR exposurephotoprotectionreviewvitamin D

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Area of Science:

  • Dermatology
  • Endocrinology
  • Public Health

Background:

  • Sunscreen photoprotection impacts vitamin D (25(OH)D) formation.
  • Ultraviolet radiation (UVR) poses risks for skin cancer.
  • Balancing photoprotection and vitamin D synthesis is crucial.

Purpose of the Study:

  • To review the effects of sunscreen on 25(OH)D formation.
  • To identify optimal sunscreen application methods for UVR protection.
  • To assess vitamin D levels after simulated sun exposure with sunscreen.

Main Methods:

  • Review of existing studies on sunscreen use and 25(OH)D levels.
  • Estimation of 25(OH)D formation based on UVR exposure and sunscreen application.
  • Analysis of different sunscreen application techniques and amounts.

Main Results:

  • Two consecutive sunscreen applications before exposure are most effective.
  • Sufficient sunscreen amounts and minimal exposed skin maximize photoprotection.
  • Calculated serum 25(OH)D levels increased significantly despite sunscreen use.

Conclusions:

  • The double-application sunscreen method provides superior photoprotection against erythema.
  • Optimal photoprotection strategies can maintain adequate vitamin D levels.
  • Sunscreen use does not preclude achieving sufficient 25(OH)D levels post-vacation.