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Recent advances of drug delivery nanocarriers in osteosarcoma treatment
Shang-Yu Wang1, Hong-Zhi Hu1, Xiang-Cheng Qing1
1Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Abstract:
Osteosarcoma is the most common primary malignant bone tumor mainly occurred in children and adolescence, and chemotherapy is limited for the side effects and development of drug resistance. Advances in nanotechnology and knowledge of cancer biology have led to significant improvements in developing tumor-targeted drug delivery nanocarriers, and some have even entered clinically application. Delivery of chemotherapeutic agents by functionalized smart nanocarriers could protect the drugs from rapid clearance, prolong the circulating time, and increase the drug concentration at tumor sites, thus enhancing the therapeutic efficacy and reducing side effects. Various drug delivery nanocarriers have been designed and tested for osteosarcoma treatment, but most of them are still at experimental stage, and more further studies are needed before clinical application. In this present review, we briefly describe the types of commonly used nanocarriers in osteosarcoma treatment, and discuss the strategies for osteosarcoma-targeted delivery and controlled release of drugs. The application of nanoparticles in the management of metastatic osteosarcoma is also briefly discussed. The purpose of this article is to present an overview of recent progress of nanoscale drug delivery platforms in osteosarcoma, and inspire new ideas to develop more effective therapeutic options.
Insights
Nanotechnology offers improved chemotherapy for osteosarcoma (a common bone cancer). Nanocarriers enhance drug delivery to tumors, boosting efficacy and reducing side effects, though clinical application requires further research.
Area of Science:
- Oncology
- Nanotechnology
- Biomedical Engineering
Background:
- Osteosarcoma is a prevalent pediatric bone cancer with limited chemotherapy options due to side effects and drug resistance.
- Nanotechnology advancements enable the development of targeted drug delivery systems for improved cancer treatment.
Purpose of the Study:
- To review current nanocarrier platforms for osteosarcoma treatment.
- To discuss strategies for targeted drug delivery and controlled release in osteosarcoma.
- To explore the potential of nanoparticles in managing metastatic osteosarcoma.
Main Methods:
- Review of existing literature on nanocarriers for osteosarcoma.
- Analysis of targeted delivery and controlled release strategies.
- Discussion of nanoparticle applications in metastatic osteosarcoma.
Main Results:
- Various nanocarriers show promise for osteosarcoma treatment, with some nearing clinical application.
- Functionalized nanocarriers can protect drugs, prolong circulation, and increase tumor drug concentration.
- Targeted delivery and controlled release strategies enhance therapeutic efficacy and reduce side effects.
Conclusions:
- Nanoscale drug delivery platforms represent a significant advancement in osteosarcoma management.
- Further research is essential to translate experimental nanocarrier systems into clinical practice.
- Nanotechnology holds potential for developing more effective therapeutic options for osteosarcoma, including metastatic forms.
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