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Selective interstitial doxorubicin for recurrent glioblastoma
Valerii Matcovschii1, Dan Lisii1, Valentin Gudumac2
1Neurosurgery Department Institute of Neurology Institute of Neurology and Neurosurgery Chisinau Moldova.
Clinical Case Reports
|January 2, 2020
Summary
Interstitial chemotherapy offers a promising approach for brain tumors, bypassing the blood-brain barrier. This method may allow effective doxorubicin delivery to tumor cells while minimizing neurotoxicity.
Area of Science:
- Neuro-oncology
- Pharmacology
- Biomedical Engineering
Background:
- Intravenous chemotherapy faces challenges in treating brain tumors due to poor tumor delimitation, genetic heterogeneity, and lack of vascularization.
- The blood-brain barrier restricts the efficacy of systemic drug delivery for central nervous system malignancies.

