Development and use of analytical systems based on mass spectrometry

Area of Science:

• Analytical Chemistry
• Mass Spectrometry

Background:

• Mass spectrometry systems typically use gas chromatography and electron impact or chemical ionization.
• Key developments include molecule separators, mass spectrometers as detectors, chemical ionization, and computer automation.

Purpose of the Study:

• To describe atmospheric pressure ionization mass spectrometry (API-MS).
• To highlight its versatility and sensitivity for various analytical applications.

Main Methods:

• Samples are ionized in a chamber external to the mass analyzer using electron sources like 63Ni foil or corona discharge.
• Ionization involves ion-molecule reactions, forming positive and negative ions.
• Samples can be introduced in gas or liquid phases, compatible with gas chromatography and high-performance liquid chromatography.

Main Results:

• Atmospheric pressure ionization mass spectrometry demonstrates high sensitivity and detection versatility.
• The technique accepts various gases and solvents for sample introduction.

Conclusions:

• API-MS offers novel capabilities for sensitive detection.
• Future applications include therapeutic drug monitoring, drug metabolism studies, and environmental analysis of toxins like pesticides and dioxins.