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Comparative effects of 2.5mg levamlodipine and 5mg amlodipine on vascular endothelial function and atherosclerosis

Yinhui Lu1, Juan Yin1, Xiaohe Wu1

  • 1Department of Gerontology, Jiangxi Provincial People's Hospital, Nanchang, PR China.

Pakistan Journal of Pharmaceutical Sciences
|January 3, 2020
PubMed

Insights

Amlodipine 5mg significantly improved hypertension outcomes in elderly patients compared to levamlodipine 2.5mg. The higher dosage enhanced vascular function, reduced atherosclerosis, and lowered adverse events, leading to shorter treatment durations.

Area of Science:

  • Cardiology
  • Pharmacology
  • Geriatrics

Background:

  • Hypertension is a prevalent condition in elderly patients, increasing risks for cardiovascular events.
  • Vascular endothelial function and atherosclerosis are critical indicators of cardiovascular health in aging populations.

Purpose of the Study:

  • To compare the efficacy of amlodipine 5mg versus levamlodipine 2.5mg in elderly hypertensive patients.
  • To evaluate the drugs' impact on vascular endothelial function and atherosclerosis progression.
  • To assess safety and patient satisfaction profiles of both treatments.

Main Methods:

  • 84 elderly hypertensive patients were randomized into two groups: control (levamlodipine 2.5mg) and treatment (amlodipine 5mg).
  • Efficacy was assessed by blood pressure control, recovery time, and overall effective rate.
  • Vascular endothelial function, atherosclerosis markers (carotid intima-media thickness, plaque), and adverse events were monitored.

Main Results:

  • Amlodipine 5mg group showed a significantly higher total effective rate (90.5%) than the control group (71.4%).
  • Treatment group experienced faster recovery of indicators, shorter medication duration, and fewer adverse drug reactions (1 vs 6).
  • Significant improvements were observed in fingertip pulse volume, brachial artery flow-mediated dilation, endothelin-1 levels, and carotid atherosclerosis markers in the amlodipine 5mg group.

Conclusions:

  • Amlodipine 5mg is more effective than levamlodipine 2.5mg in managing hypertension in elderly patients.
  • Amlodipine 5mg demonstrates superior benefits in improving endothelial function and mitigating atherosclerosis.
  • The higher dosage of amlodipine offers enhanced efficacy, improved safety, and greater patient satisfaction.

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