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Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug
Published on: May 17, 2024
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Antihypertensive constituents in Sanoshashinto
Jianbo Wu1, Souichi Nakashima1, Marina Shigyo1
1Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.
Journal of Natural Medicines
|January 3, 2020
Summary
Sanoshashinto, a herbal remedy, demonstrates significant vasorelaxant and antihypertensive effects. Its key active compounds, baicalin and berberine, effectively lower blood pressure by influencing vascular pathways.
Area of Science:
- Pharmacology
- Herbal Medicine
- Cardiovascular Research
Background:
- Sanoshashinto (SanHuangXieXinTang) is a traditional Chinese medicine composed of Rhei Rhizoma, Scutellariae Radix, and Coptidis Rhizoma.
- Previous reports indicate Sanoshashinto possesses vasorelaxant properties and can lower blood pressure in patients.
Purpose of the Study:
- To investigate the vasorelaxant and antihypertensive effects of Sanoshashinto extracts and identify its active constituents.
- To elucidate the potential mechanisms underlying its pharmacological actions.
Main Methods:
- Methanol extracts and fractions of Sanoshashinto were prepared and tested for their effects on isolated rat aortic rings and helical strips.
- High-performance liquid chromatography (HPLC) was used for qualitative and quantitative analysis of the extracts.
- Spontaneously hypertensive rats (SHRs) were used to evaluate in vivo antihypertensive effects.
Main Results:
- Sanoshashinto methanol extract (SHXXTM) and its fractions exhibited significant vasorelaxant effects against high potassium chloride (High K+) and noradrenaline (NA)-induced contractions.
- HPLC analysis revealed high contents of baicalin and berberine in SHXXTM.
- Oral administration of SHXXTM or a baicalin-berberine combination significantly reduced systolic blood pressure (SBP) in SHRs.
Conclusions:
- Sanoshashinto possesses notable in vitro vasorelaxant and in vivo antihypertensive effects.
- Baicalin and berberine are identified as the primary antihypertensive constituents of Sanoshashinto.
- The vasorelaxant effects are likely mediated through the NO/cGMP pathway, with potential involvement of BKCa channels and the DAG/PKC/CPI-17 pathway.
Keywords:
AntihypertensiveBaicalinBerberinePrincipal component analysisSanoshashintoVasorelaxant effectMore Related Videos
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