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Inflammation, Frailty and Cardiovascular Disease
Pinar Soysal1, Ferhat Arik2, Lee Smith3
1Department of Geriatric Medicine, Faculty of Medicine, Bezmialem Vakif University, Adnan Menderes Bulvarı (Vatan Street), 34093, Fatih, Istanbul, Turkey. dr.pinarsoysal@hotmail.com.
Advances in Experimental Medicine and Biology
|January 3, 2020
Summary
Chronic inflammation, known as inflamm-aging, contributes to age-related diseases. This chapter explores its link to cardiovascular diseases (CVD) and frailty in older adults.
Area of Science:
- Gerontology
- Immunology
- Cardiovascular Medicine
Background:
- Inflamm-aging is chronic, low-grade inflammation associated with aging.
- It results from stressors and impairs immune function.
- Causes include genetics, obesity, gut dysbiosis, infections, and senescence.
Purpose of the Study:
- To discuss the role of inflamm-aging in age-related diseases.
- To explore the relationship between inflammation, cardiovascular diseases (CVD), and frailty.
Main Methods:
- Literature review and synthesis of existing research on inflammation, aging, CVD, and frailty.
Main Results:
- Chronic inflammation is implicated in frailty development.
- Low-grade chronic inflammation increases risks for atherosclerosis and insulin resistance, key factors in CVD.
- A potential bidirectional relationship exists between CVD and frailty, mediated by inflammation.
Conclusions:
- Inflamm-aging is a significant factor in the pathogenesis of age-related conditions.
- Understanding the inflammation-CVD-frailty nexus is crucial for geriatric health.
- Further research is warranted to elucidate these complex interactions.
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