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Related Concept Videos

Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Whole Body Regeneration01:33

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Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential;...
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Integrated Healthcare System01:20

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An integrated healthcare system (IHS) is a set of organizations that provides for or arranges to provide coordinated and continuous service to a defined population. The IHS takes responsibility for that particular population's health status and outcome, both clinically and fiscally. An integrated healthcare system is a well-organized, well-coordinated, and collaborative network. The integrated delivery system is a network that connects different healthcare providers to deliver organized,...
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Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Mitochondria01:37

Mitochondria

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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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Related Experiment Video

Updated: Dec 31, 2025

Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty
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Healthy aging: the INTECMAN project.

Marco Laurino1, Gaspare Alfì2, Lucia Billeci3

  • 1Institute of Clinical Physiology, National Research Council, Via Moruzzi 1, Pisa, Italy. laurino@ifc.cnr.it.

Aging Clinical and Experimental Research
|January 3, 2020
PubMed
Summary

This pilot study shows that 12-month tailored lifestyle counseling can improve mild cognitive impairment in older adults. This approach supports healthy aging and self-sufficiency at home.

Keywords:
AgingCognitive impairmentLife-stylePsychophysical capacities

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Area of Science:

  • Gerontology and Cognitive Health
  • Neuroscience and Aging Research

Background:

  • Aging is linked to declining psychophysical and sensory abilities, increasing risks of neurodegenerative disorders and dementia.
  • Maintaining health and self-sufficiency in aging populations requires preventing and correcting factors affecting psychophysical capacities.
  • Technological advancements like noninvasive physiological monitoring and telemedicine offer support for in-home care and better aging.

Purpose of the Study:

  • To assess the impact of a 12-month individually tailored lifestyle counseling program on parameters of mild cognitive impairment in elderly subjects.
  • To explore the potential of personalized, multiparametric monitoring for supporting healthy aging in a home setting.

Main Methods:

  • A pilot study involving elderly subjects with mild cognitive impairment.
  • Implementation of a 12-month individually tailored lifestyle counseling intervention.
  • Monitoring of various psychophysical variables using non-obtrusive technologies.

Main Results:

  • The data derived from the applied approach showed promising results in addressing mild cognitive impairment.
  • The study demonstrated the feasibility of personalized, multiparametric monitoring for elderly individuals at home.

Conclusions:

  • Individually tailored lifestyle counseling shows potential for improving cognitive parameters in the elderly.
  • Multiparametric, non-obtrusive home-based technologies can support psychological and physical aspects of better aging.