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Do tone duration changes that elicit the mismatch negativity also affect the preceding middle latency responses?
Yusuke Osakabe1, Tetsuya Shiga1, Hiroshi Hoshino1
1Department of Neuropsychiatry, Fukushima Medical University, Fukushima City, Japan.
The European Journal of Neuroscience
|January 3, 2020
Summary
The human brain detects sound changes automatically. While sound location changes enhance middle latency responses (MLR), duration changes did not affect MLR amplitude, though mismatch negativity (MMN) was observed.
Area of Science:
- Neuroscience
- Auditory Perception
- Brain Response to Stimuli
Background:
- The human brain automatically detects auditory changes.
- Rare sounds elicit mismatch negativity (MMN) (100-250 ms) without attention.
- Sound location changes enhance middle latency responses (MLR) (10-50 ms).
Purpose of the Study:
- To investigate if duration changes in auditory stimuli affect MLR peak amplitudes.
- To compare MLR responses to standard and deviant duration stimuli in an oddball paradigm.
Main Methods:
- Utilized an oddball paradigm with standard (10 ms) and deviant (5 ms) sound durations.
- Recorded and analyzed peak amplitudes of MLR components in 20 healthy male participants.
- Compared MLR amplitudes between standard and deviant stimuli.
Main Results:
- No significant change in MLR peak amplitude was observed due to sound duration changes.
- A distinct mismatch negativity (MMN) was elicited by the duration change.
- MLR amplitude increases were noted for frequency and location oddball paradigms, but not for duration changes.
Conclusions:
- Sound duration changes alone do not appear to enhance MLR peak amplitudes.
- The auditory system differentiates sound duration changes, evidenced by MMN.
- MLR is sensitive to location and frequency changes, but not duration changes in this paradigm.
