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Diffuse uveal melanoma in a 5-year-old child
P S Rosenbaum1, M Boniuk, R L Font
1Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas 77030.
American Journal of Ophthalmology
|November 15, 1988
Summary
A pediatric malignant melanoma of the iris presented as eye discoloration and thickened iris. This rare cancer later metastasized, highlighting the need for early detection in children.
Area of Science:
- Ophthalmology
- Pediatric Oncology
- Pathology
Background:
- Malignant melanoma of the iris is a rare ocular tumor, particularly in children.
- Early diagnosis and treatment are crucial for managing ocular cancers.
Observation:
- A 5-year-old boy presented with iris discoloration and thickening, indicative of a potential ocular abnormality.
- Ophthalmologic examination revealed keratic precipitates, anterior synechiae, and choroidal infiltrates.
Findings:
- Cytology and iris biopsy confirmed malignant melanoma of the iris, predominantly epithelioid cell type.
- Histopathology revealed diffuse uveal melanoma with neoplastic melanocytes and melanosome abnormalities.
- Electron microscopy showed immature and mature melanosomes within bizarre neoplastic melanocytes.
Implications:
- This case underscores the aggressive nature of pediatric iris melanoma.
- Metastasis to the nasopharynx and skull base occurred eight months post-enucleation.
- Further research into early detection and treatment strategies for pediatric ocular melanoma is warranted.