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The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

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Updated: Dec 31, 2025

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies

Published on: November 10, 2023

The microenvironment in myeloma.

Oliver C Lomas^1,2,3, Sabrin Tahri^1,2,3, Irene M Ghobrial^1,2,3

¹Dana-Farber Cancer Institute, Boston.

Current Opinion in Oncology

|January 3, 2020

Summary

This summary is machine-generated.

Recent advances reveal how multiple myeloma interacts with the bone marrow microenvironment. Targeting specific bone marrow niches may offer new therapies for earlier intervention in multiple myeloma.

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Area of Science:

Hematology
Oncology
Cancer Biology

Background:

Multiple myeloma is a hematologic malignancy characterized by complex interactions within the bone marrow microenvironment.
Understanding these interactions is crucial for developing effective therapeutic strategies.

Purpose of the Study:

To review recent advancements in understanding the interplay between multiple myeloma and its bone marrow microenvironment.
To identify potential therapeutic and prognostic targets within this microenvironment for multiple myeloma.

Main Methods:

Review of current scientific literature on multiple myeloma and bone marrow microenvironment interactions.
Analysis of emerging therapeutic targets and their clinical efficacy in ongoing trials.

Main Results:

The bone marrow microenvironment in multiple myeloma presents several targets amenable to therapy.
Current therapeutic interventions show some clinical efficacy, particularly in heavily pretreated patients.
A key challenge is determining the optimal timing for these interventions early in disease progression.

Conclusions:

Targeting specific niches within the bone marrow microenvironment holds promise for significant therapeutic benefit in multiple myeloma.
Such targeted therapies may facilitate earlier intervention, disrupting the progression-permissive environment.
Further research is needed to delineate cause-and-effect relationships and optimize early-stage treatment strategies.