Related Experiment Video
Updated: Dec 31, 2025
08:55
The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
Published on: November 30, 2016
17.0K
Cancer cachexia: a multifactoral disease that needs a multimodal approach
Renee Stubbins1, Eric H Bernicker1, Eamonn M M Quigley2
1Houston Methodist Hospital Cancer Center.
Current Opinion in Gastroenterology
|January 3, 2020
Summary
Cancer cachexia, a complex condition causing lean body mass loss, requires a multimodal treatment approach. Early detection and management involving a multidisciplinary team are crucial for improving patient outcomes.
Area of Science:
- Oncology
- Metabolism
- Nutrition Science
Background:
- Cancer cachexia affects up to 80% of advanced cancer patients.
- Characterized by lean mass loss, adipose tissue depletion, metabolic changes, inflammation, and reduced quality of life.
- A complex, multifactorial condition necessitating innovative management strategies.
Purpose of the Study:
- To review current treatments for cancer cachexia.
- To explore the integration of these treatments into a multimodal approach.
Main Methods:
- Review of existing literature on cancer cachexia treatments.
- Analysis of components for a multimodal therapeutic strategy.
Main Results:
- Cancer cachexia stems from reduced nutrient intake, altered metabolism, and inflammation.
- No formal diagnostic consensus exists; proactive malnutrition screening is recommended.
- Effective treatment involves optimizing nutrition, pharmacological interventions, preserving lean body mass, and team cooperation.
Conclusions:
- Successful management of cancer cachexia demands a multimodal strategy.
- A multidisciplinary team, including oncology-registered dietitian nutritionists and exercise physiologists, is essential.
- Early detection and integrated management are key to addressing cancer cachexia.
Related Concept Videos
02:50Combination Therapies and Personalized Medicine
5.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.8K
02:56Treatment Resistant Cancers
3.6K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.6K
02:53Adaptive Mechanisms in Cancer Cells
6.8K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
6.8K
02:49Cancer Therapies
9.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.7K
01:29Chronic Pancreatitis II: Collaborative Care
264
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
264
02:18Cancer
53.3K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
53.3K