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Related Experiment Videos

Area postrema stimulation induced cardiovascular changes in the rat.

A V Ferguson1, P Marcus

  • 1Department of Physiology, Queen's University, Kingston, Ontario, Canada.

The American Journal of Physiology
|November 1, 1988
PubMed
Summary

Electrical stimulation of the area postrema (AP) in rats rapidly decreases blood pressure and heart rate. This suggests the AP plays a key role in the body's autonomic control mechanisms.

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Area of Science:

  • Neuroscience
  • Cardiovascular Physiology
  • Autonomic Nervous System Research

Background:

  • The area postrema (AP) is a circumventricular structure involved in autonomic control.
  • Understanding the AP's role in cardiovascular regulation is crucial for neurological and physiological research.

Purpose of the Study:

  • To investigate the effects of electrical stimulation of the area postrema (AP) on cardiovascular control mechanisms.
  • To determine if AP activation influences mean arterial blood pressure and heart rate.

Main Methods:

  • Utilized low-frequency electrical stimulation (10 Hz, 200 microA) in the AP of urethane-anesthetized Sprague-Dawley rats.
  • Compared the cardiovascular effects of AP stimulation with stimulation of the adjacent nucleus tractus solitarius (NTS).

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  • Measured changes in mean arterial blood pressure and heart rate in response to stimulation.

    • Main Results:

    • Low-frequency electrical stimulation in the AP caused rapid and short-lasting decreases in mean arterial blood pressure (-34.8 +/- 2.7 mmHg).
    • AP stimulation significantly reduced heart rate, an effect not observed with NTS stimulation.
    • In contrast, NTS stimulation resulted in significant increases in blood pressure (+43.1 +/- 6.7 mmHg).

    Conclusions:

    • Activation of neural elements within the AP leads to rapid, reversible decreases in mean arterial blood pressure and heart rate.
    • These findings highlight the significant role of the AP in cardiovascular control.
    • The AP's function in autonomic control mechanisms is further emphasized by these results.