Purification and separation of ultra-small metal nanoclusters

Metal nanoclusters (NCs) are ultra-small nanoparticles intermediate in size between small molecule complexes and nanoparticles. NCs with tunable surface functionality feature unique physical and chemical properties, however these properties are frequently compromised by the presence of undesired components such as excess ligands or mixtures of NCs. In a typical synthesis process, different NCs can be formed with varying numbers of metal atoms and/or ligands, and even NCs with the same number of metal atoms and ligands can have different spatial structures. The separation of pure NCs is important because different species have distinct optical and catalytic behavior. However, NCs can be difficult to purify or separate for a range of reasons. In this review, we discuss established and emerging approaches for NC purification/separation, with a focus on choosing the appropriate method depending on NC and application.