Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

"Chasing the first high": memory sampling in drug choice.

Aaron M Bornstein1,2,3, Hanna Pickard4,5

  • 1Department of Cognitive Sciences, University of California, Irvine, CA, 92617, USA. aaron.bornstein@uci.edu.

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
|January 3, 2020
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A specific computational role for early-life unpredictability, and not lifelong traumatic experience, in decision-making under uncertainty.

bioRxiv : the preprint server for biology·2026
Same author

A Bayesian Time-Varying Psychophysiological Interaction Model.

Data science in science·2026
Same author

Anhedonia buffers the effects of early-life unpredictability on threat-reward decision-making.

bioRxiv : the preprint server for biology·2026
Same author

Structure Inference in Complex Environments Improves From Childhood to Adulthood.

Developmental science·2026
Same author

Multistep inference across the human lifespan can be improved with individualized memory interventions.

The journals of gerontology. Series B, Psychological sciences and social sciences·2026
Same author

Cognitive Graphs: Representational Substrates for Planning.

Decision (Washington, D.C.)·2025
Same journal

Cultural humility in the teaching and practice of clinical care.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
Same journal

Kappa opioid receptors mediate aversion-and it matters.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
Same journal

Splice isoforms of the histone variant macroH2A1 differentially regulate hippocampal gene expression and memory formation.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
Same journal

Chronic ethanol self-administration alters dopamine in the caudate nucleus and putamen of rhesus macaques in a sex-dependent manner.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
Same journal

In memoriam-Shigeto Yamawaki, M.D., Ph.D. (1954-2026).

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
Same journal

Top-down control of sustained attention by medial prefrontal cortex-locus coeruleus (mPFC-LC) projection neurons during the rodent continuous performance test (rCPT).

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
See all related articles

Vivid drug memories influence addiction by biasing choices during persistent use and relapse. Novel treatments should create new associations between drug cues and non-drug rewards, rather than breaking old ones.

Area of Science:

  • Cognitive Neuroscience
  • Neurobiology of Addiction
  • Behavioral Psychology

Background:

  • Vivid memories of drug experiences are common in addiction contexts.
  • The role of memory retrieval in substance use disorder (SUD) is not well understood.
  • Episodic memory influences reward-based decision-making.

Purpose of the Study:

  • To propose a framework linking memory retrieval to drug choices in SUD.
  • To explore how memory influences the two phases of addiction: persistent use and relapse.
  • To suggest novel treatment strategies for SUD based on memory processes.

Main Methods:

  • Review and synthesis of existing research on memory retrieval and decision-making.
  • Development of a theoretical framework for memory's role in addiction.

Related Experiment Videos

  • Conceptualization of treatment implications based on the proposed framework.

    • Main Results:

    • Drug choices are proposed to be biased by selective sampling of memories.
    • This memory bias operates during the downward spiral into persistent use.
    • Memory retrieval also influences relapse into substance use.

    Conclusions:

    • Memory retrieval significantly impacts the addiction process.
    • Novel SUD treatments should focus on creating new associations with drug cues.
    • Strengthening associations with drug-inconsistent rewards offers a promising therapeutic avenue.