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BMSC-EVs regulate Th17 cell differentiation in UC via H3K27me3

Qianyun Chen1, Xueyun Duan2, Meng Xu1

  • 1Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Molecular Immunology
|January 4, 2020
PubMed
Summary

Mesenchymal stem cell extracellular vesicles reduce ulcerative colitis by inhibiting Th17 cell differentiation. This effect is linked to changes in histone H3K27me3 levels, suggesting a novel therapeutic target for inflammatory diseases.

Keywords:
Bone marrow mesenchymal stem cell extracellular vesiclesH3K27me3Th17 cellsUlcerative colitis

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