Whole-Genome Sequences of Two NDM-1-Producing Pseudomonas aeruginosa Strains Isolated in a Clinical Setting in
Silva Tafaj1, Floriana Gona2, Célia F Rodrigues3
1Microbiology Department, University Hospital Shefqet Ndroqi, Tirana, Albania stafaj@hotmail.com.
Abstract:
Isolation of metallo-β-lactamase-producing, carbapenem-resistant, Pseudomonas aeruginosa strains is increasingly being documented worldwide; their presence constitutes a public health threat. Here, we report draft genome sequences of two New Delhi metallo-β-lactamase-1-producing, multidrug-resistant, P. aeruginosa strains of sequence type 235 that were isolated from the surgical wound of two patients hospitalized in the same ward.
Insights
Two multidrug-resistant Pseudomonas aeruginosa strains producing New Delhi metallo-β-lactamase-1 were isolated from surgical wounds. These carbapenem-resistant strains pose a significant public health threat due to their increasing global prevalence.
Area of Science:
- Microbiology
- Genomics
- Infectious Diseases
Background:
- Metallo-β-lactamase-producing, carbapenem-resistant Pseudomonas aeruginosa strains are a growing global health concern.
- These resistant strains are increasingly documented worldwide, posing a significant public health threat.
Purpose of the Study:
- To report the draft genome sequences of two specific multidrug-resistant P. aeruginosa strains.
- To characterize New Delhi metallo-β-lactamase-1 producing P. aeruginosa strains of sequence type 235.
Main Methods:
- Whole-genome sequencing was performed to obtain draft genome sequences.
- Bacterial strains were isolated from surgical wound infections in hospitalized patients.
Main Results:
- Draft genome sequences for two New Delhi metallo-β-lactamase-1 producing, multidrug-resistant P. aeruginosa strains (ST 235) were generated.
- These strains were isolated from surgical wounds of patients in the same hospital ward.
Conclusions:
- The availability of these genome sequences aids in understanding the epidemiology and evolution of these critical pathogens.
- Continued surveillance and characterization of such strains are crucial for public health.
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