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Updated: Dec 31, 2025
Author Spotlight: Development of an Enhanced Protocol for Rapid and Accurate Isolation of Campylobacter from Food Products
Published on: February 23, 2024
Draft Genome Sequences of Multidrug-Resistant Campylobacter jejuni Strains Isolated from Chickens in Central China
Yiluo Cheng1, Wenting Zhang1, Qin Lu1
1Key Laboratory of Prevention and Control Agents for Animal Bacteriosis, Institute of Animal Husbandry and Veterinary, Hubei Academy of Agricultural Sciences, Wuhan, China.
Abstract:
Campylobacter jejuni is a major foodborne pathogen that plays an important role in spreading drug resistance. We report the draft genome sequences of two multidrug-resistant C. jejuni isolates which contained similar mutations in the CmeR box. This will improve the understanding of C. jejuni antimicrobial resistance and genetic characteristics.
Insights
Two multidrug-resistant Campylobacter jejuni strains were sequenced, revealing shared mutations in the CmeR box. This research enhances understanding of Campylobacter jejuni antimicrobial resistance and genetic traits.
Area of Science:
- Microbiology
- Genomics
- Antimicrobial Resistance
Background:
- Campylobacter jejuni is a significant foodborne pathogen.
- Antimicrobial resistance in C. jejuni is a growing public health concern.
- Understanding the genetic basis of resistance is crucial for effective treatment.
Purpose of the Study:
- To report the draft genome sequences of two multidrug-resistant C. jejuni isolates.
- To investigate genetic characteristics associated with antimicrobial resistance in C. jejuni.
- To identify specific mutations contributing to drug resistance.
Main Methods:
- Whole-genome sequencing of two C. jejuni isolates.
- Bioinformatic analysis of genomic data.
- Identification and comparison of mutations, particularly in the CmeR regulatory region.
Main Results:
- The draft genome sequences of two multidrug-resistant C. jejuni isolates were obtained.
- Similar mutations were identified in the CmeR regulatory box of both isolates.
- These mutations are potentially linked to the observed multidrug resistance phenotype.
Conclusions:
- The genomic data provides insights into the genetic underpinnings of antimicrobial resistance in C. jejuni.
- Identification of CmeR box mutations advances the understanding of C. jejuni's resistance mechanisms.
- This study contributes to characterizing the genetic landscape of drug-resistant C. jejuni.
